Efforts to reach the full therapeutic potential of macromolecules (biopharmaceuticals) for clinical care are thus limited by a lack of effective, efficient and convenient drug delivery. In some ways this is the same challenge for small molecules: improving the efficacy to toxicity ratio by focusing and improving the interaction with its intended target. The drug delivery mantra of getting the right drug to the right place for the right amount of time provides a good starting point to address limitations of both small molecules and macromolecular therapeutics.
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Learn more about:
- Pathways for macromolecule transport across biological membranes and how scientists can take advantage of these in order to deliver their molecule to the body.
- Drug delivery methods that have been necessary to overcome the various physical, physiological, and biochemical barriers that limit macromolecular drug delivery.
- Identifying non-invasive (or minimally invasive) methods of delivering macromolecules to not only improve compliance but also therapeutic benefit.